Methods for unsupervised domain adaptation (UDA) help to improve the performance of deep neural networks on unseen domains without any labeled data. Especially in medical disciplines such as histopathology, this is crucial since large datasets with detailed annotations are scarce. While the majority of existing UDA methods focus on the adaptation from a labeled source to a single unlabeled target domain, many real-world applications with a long life cycle involve more than one target domain. Thus, the ability to sequentially adapt to multiple target domains becomes essential. In settings where the data from previously seen domains cannot be stored, e.g., due to data protection regulations, the above becomes a challenging continual learning problem. To this end, we propose to use generative feature-driven image replay in conjunction with a dual-purpose discriminator that not only enables the generation of images with realistic features for replay, but also promotes feature alignment during domain adaptation. We evaluate our approach extensively on a sequence of three histopathological datasets for tissue-type classification, achieving state-of-the-art results. We present detailed ablation experiments studying our proposed method components and demonstrate a possible use-case of our continual UDA method for an unsupervised patch-based segmentation task given high-resolution tissue images.

Image super-resolution (SR) is one of the vital image processing methods that improve the resolution of an image in the field of computer vision. In the last two decades, significant progress has been made in the field of super-resolution, especially by utilizing deep learning methods. This survey is an effort to provide a detailed survey of recent progress in single-image super-resolution in the perspective of deep learning while also informing about the initial classical methods used for image super-resolution. The survey classifies the image SR methods into four categories, i.e., classical methods, supervised learning-based methods, unsupervised learning-based methods, and domain-specific SR methods. We also introduce the problem of SR to provide intuition about image quality metrics, available reference datasets, and SR challenges. Deep learning-based approaches of SR are evaluated using a reference dataset. Some of the reviewed state-of-the-art image SR methods include the enhanced deep SR network (EDSR), cycle-in-cycle GAN (CinCGAN), multiscale residual network (MSRN), meta residual dense network (Meta-RDN), recurrent back-projection network (RBPN), second-order attention network (SAN), SR feedback network (SRFBN) and the wavelet-based residual attention network (WRAN). Finally, this survey is concluded with future directions and trends in SR and open problems in SR to be addressed by the researchers.